Non‐Toxic Glycosylated Gold Nanoparticle‐Amphotericin B Conjugates Reduce Biofilms and Intracellular Burden of Fungi and Parasites

Infections by intracellular pathogens cause significant morbidity and mortality due to lack of efficient drug delivery. Amphotericin B, currently used treat leishmaniasis cryptococcosis, is very toxic cannot eradicate Cryptococcus neoformans (C. neoformans). Glycosylated gold nanoparticles are water dispersible biocompatible with little toxicity. While amphotericin B insoluble in at neutral pH, conjugates ultra-small (AuNP) better water. conjugated glycosylated ([email protected]) more efficacious treating both extracellular forms Leishmania mexicana (L. mexicana) than alone. In addition, [email protected] effective reducing C. biofilms 80% burden >90%. Furthermore, not haemolytic 50 µg mL−1 significantly less murine macrophages B. Ultra-small AuNPs attractive delivery agents infections may be useful for immunocompromised patients.